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Sir William Twysden, 1st Baronet (1566–1628) was an English politician who sat in the House of Commons at various times between 1593 and 1628.

Lady Anne Twysden (née Finch; 28 February 1574 – 14 October 1638) was an English writer. She was the mother of several notable children but she is known principally for one book, the original of which is lost.