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The gens Rupilia, occasionally written Rupillia, was a minor plebeian family at ancient Rome. Members of this gens are first mentioned in the latter part of the Republic, and Publius Rupilius obtained the consulship in 132 BC. Few others achieved any prominence, but the name occurs once or twice in the consular fasti under the Empire. The name is frequently confounded with the similar Rutilius.

Marcus Annius Verus (c. 50 – 138 AD) was the paternal grandfather and adoptive father of the Roman Emperor Marcus Aurelius, and father-in-law of the emperor Antoninus Pius.