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Quispe Sisa (c. 1518 – 1559), also known as Inés Huaylas Yupanqui, was an Inca princess, daughter of the Sapa Inca Huayna Capac. She played a role in the Spanish conquest of the Inca Empire. The Palace of the Conquest in Trujillo, Spain features busts of her, her daughter Francisca Pizarro Yupanqui, Francisco Pizarro and her daughter's husband, Hernando Pizarro.